Chapter 9. Assay of Factor VIII and Other Clotting Factors

  1. Steve Kitchen PhD Clinical Scientist Scientific Director1,2,3,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs4 and
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director5,6
  1. S. Kitchen PhD Clinical Scientist Scientific Director1,2,3 and
  2. F. E. Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director5,6

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch9

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

How to Cite

Kitchen, S. and Preston, F. E. (2008) Assay of Factor VIII and Other Clotting Factors, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch9

Editor Information

  1. 1

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 2

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 3

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 4

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 5

    University of Sheffield, Sheffield, UK

  6. 6

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. 1

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 2

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 3

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 5

    University of Sheffield, Sheffield, UK

  5. 6

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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Keywords:

  • assay of clotting factors in plasma and emphasis on factor VIII:C;
  • one-stage assay of factors VIII:C or IX:C;
  • lupus anticoagulant (LAC);
  • one-stage assay components;
  • assay of clotting factors;
  • factor assays in presence of severe deficiency;
  • two-stage clotting assay for FVIII:C;
  • chromogenic assay for FVIII:C in plasma

Summary

This chapter contains sections titled:

  • Pretest variables

  • One-stage assay of factors VIII:C or IX:C

  • One-stage assay components

  • Factor assays in the presence of severe deficiency

  • Assay of elevated FVIII:C

  • Two-stage clotting assay for FVIII:C

  • Chromogenic assay for FVIII:C in plasma

  • Factor VIII:C and FIX:C assays following clotting factor infusions

  • References