Chapter 23. Severe Sepsis and Septic Shock

  1. Brian H. Rowe MD, MSc, CCFP(EM), FCCP Professor Research Director
  1. Peter W. Greenwald MD Visiting Assistant Professor of Medicine1,
  2. Scott Weingart MD Director2 and
  3. H. Bryant Nguyen MD, MS Associate Professor3

Published Online: 27 FEB 2009

DOI: 10.1002/9781444303674.ch23

Evidence-Based Emergency Medicine

Evidence-Based Emergency Medicine

How to Cite

Greenwald, P. W., Weingart, S. and Nguyen, H. B. (2008) Severe Sepsis and Septic Shock, in Evidence-Based Emergency Medicine (ed B. H. Rowe), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303674.ch23

Editor Information

  1. Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada

Author Information

  1. 1

    Division of Emergency Medicine, New York–Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA

  2. 2

    Division of Emergency Critical Care, Department of Emergency Medicine, Mount Sinai School of Medicine, New York, USA

  3. 3

    Departments of Emergency Medicine and Medicine, Division of Pulmonary and Critical Care Medicine, Loma Linda University, Loma Linda, California, USA

Publication History

  1. Published Online: 27 FEB 2009
  2. Published Print: 31 OCT 2008

ISBN Information

Print ISBN: 9781405161435

Online ISBN: 9781444303674



  • severe sepsis and septic shock;
  • Systemic inflammatory response syndrome (SIRS);
  • Severe sepsis is sepsis associated with organ dysfunction;
  • recombinant human activated protein C (rhAPC) administration;
  • Multiple Organ Dysfunction Score (MODS);
  • Acute Physiology and Chronic Health Evaluation (APACHE);
  • Mortality probability models (MPM) II and III;
  • vasopressor use in severe sepsis and septic shock;
  • CORTICUS trial and Annane study


This chapter contains sections titled:

  • Case scenario

  • Background

  • Clinical questions

  • General search strategy

  • Critical review of the literature

  • Conclusions

  • Acknowledgments

  • References