Chapter 27. General Toxicology

  1. Brian H. Rowe MD, MSc, CCFP(EM), FCCP Professor Research Director
  1. Luke Yip MD, FACMT, FACEM, FACEP Consultant Attending Faculty Attending Staff Physician Clinical Assistant Professor1,2,3,4,
  2. Nicole Bouchard MD Assistant Clinical Professor Director of Medical Toxicology5,6 and
  3. Marco L. A. Sivilotti MD, MSc, FRCPC, FACEP, FACMT Associate Professor Consultant7,8

Published Online: 27 FEB 2009

DOI: 10.1002/9781444303674.ch27

Evidence-Based Emergency Medicine

Evidence-Based Emergency Medicine

How to Cite

Yip, L., Bouchard, N. and Sivilotti, M. L. A. (2008) General Toxicology, in Evidence-Based Emergency Medicine (ed B. H. Rowe), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303674.ch27

Editor Information

  1. Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada

Author Information

  1. 1

    Department of Emergency, The Prince Charles Hospital, Chermside, Queensland, Australia

  2. 2

    Rocky Mountain Poison and Drug Center, Denver, Colorado, USA

  3. 3

    Department of Medicine, Division of Medical Toxicology, Denver Health Medical Center, Denver, Colorado, USA

  4. 4

    School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado, USA

  5. 5

    Emergency Medicine Department, New York–Presbyterian Hospital, Columbia University Medical Center, New York, USA

  6. 6

    New York City Poison Control Center, New York, USA

  7. 7

    Departments of Emergency Medicine and Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada

  8. 8

    Ontario Poison Centre, Toronto, Ontario, Canada

Publication History

  1. Published Online: 27 FEB 2009
  2. Published Print: 31 OCT 2008

ISBN Information

Print ISBN: 9781405161435

Online ISBN: 9781444303674



  • general toxicology;
  • controlled clinical trials (CCTs);
  • gastrointestinal decontamination (GID) for ingested poisons;
  • Cochrane and MEDLINE: charcoal AND overdose AND (RCTs OR systematic reviews);
  • initial GID of heterogeneous adult population in ED following acute oral drug overdose;
  • alcohol-related seizures (ARSs);
  • rapid control of seizures - goal in emergency medicine to reduce aspiration


This chapter contains sections titled:

  • Clinical scenario

  • Background

  • Clinical questions

  • General search strategy

  • Conclusions

  • Critical review of the literature

  • Acknowledgments

  • Conflicts of interest

  • References