Chapter 28. Toxicology: Acetaminophen and Salicylate Poisoning

  1. Brian H. Rowe MD, MSc, CCFP(EM), FCCP Professor Research Director
  1. Mark Yarema MD, FRCPC Division Chief1 and
  2. Richard Dart MD, PhD Director2

Published Online: 27 FEB 2009

DOI: 10.1002/9781444303674.ch28

Evidence-Based Emergency Medicine

Evidence-Based Emergency Medicine

How to Cite

Yarema, M. and Dart, R. (2008) Toxicology: Acetaminophen and Salicylate Poisoning, in Evidence-Based Emergency Medicine (ed B. H. Rowe), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303674.ch28

Editor Information

  1. Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada

Author Information

  1. 1

    Research Department of Emergency Medicine, Calgary Health Region, Calgary, Alberta, Canada

  2. 2

    Rocky Mountain Poison and Drug Center, Denver, Colorado, USA

Publication History

  1. Published Online: 27 FEB 2009
  2. Published Print: 31 OCT 2008

ISBN Information

Print ISBN: 9781405161435

Online ISBN: 9781444303674



  • toxicology - acetaminophen and salicylate poisoning;
  • Cochrane Library, MEDLINE and EMBASE for systematic reviews and meta-analyses;
  • BestBETs review from Manchester Royal Infirmary;
  • hepatotoxicity and serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT);
  • MEDLINE, Cochrane and EMBASE: exp salicylate AND exp poisoning AND (exp charcoal OR activated charcoal);
  • gastric lavage;
  • urinary alkalinization for salicylate poisoning;
  • sustained low-efficiency dialysis (SLED)


This chapter contains sections titled:

  • Case scenario

  • Background

  • Clinical questions

  • General search strategy

  • Critical review of the literature: acetaminophen

  • Critical review of the literature: salicylate

  • Conclusions

  • Conflicts of interest

  • References