Chapter 3. Measurement of Oxidative DNA Damage by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry

  1. J. M. Rosenfeld
  1. Miral Dizdaroglu

Published Online: 3 MAR 2009

DOI: 10.1002/9781444305500.ch3

Sample Preparation for Hyphenated Analytical Techniques

Sample Preparation for Hyphenated Analytical Techniques

How to Cite

Dizdaroglu, M. (2009) Measurement of Oxidative DNA Damage by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry, in Sample Preparation for Hyphenated Analytical Techniques (ed J. M. Rosenfeld), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444305500.ch3

Editor Information

  1. Faculty of Health Science, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5

Author Information

  1. Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Bldg 227/A243, Gaithersburg, MD 20899-8311, USA

Publication History

  1. Published Online: 3 MAR 2009
  2. Published Print: 27 SEP 2004

ISBN Information

Print ISBN: 9781405111065

Online ISBN: 9781444305500

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Keywords:

  • oxidative DNA damage resulting from reactions of oxygen-derived species;
  • measurement using mass spectrometric techniques;
  • European Standards Committee for Oxidative DNA Damage (ESCODD);
  • oxidative DNA damage measured by GC/MS and LC/MS;
  • gas chromatography–mass spectrometry;
  • volatile trimethylsilyl (TMS) derivatives of bases and nucleosides;
  • enzymic hydrolysis;
  • separation and identification;
  • liquid chromatography–mass spectrometry;
  • National Institute of Standards and Technology

Summary

This chapter contains sections titled:

  • Introduction

  • Measurement using mass spectrometric techniques

  • Gas chromatography–mass spectrometry

  • Liquid chromatography–mass spectrometry

  • Artifacts

  • Disclaimer

  • References