Chapter 6. Hyphenated Techniques in Drug Discovery: Purity Assessment, Purification, Quantitative Analysis and Metabolite Identification

  1. J. M. Rosenfeld
  1. Jenny Kingston1,
  2. Desmond O'Connor2,
  3. Tim Sparey3,
  4. Steven Thomas1

Published Online: 3 MAR 2009

DOI: 10.1002/9781444305500.ch6

Book Title

Sample Preparation for Hyphenated Analytical Techniques

Sample Preparation for Hyphenated Analytical Techniques

Additional Information

How to Cite

Kingston, J., O'Connor, D., Sparey, T. and Thomas, S. (2009) Hyphenated Techniques in Drug Discovery: Purity Assessment, Purification, Quantitative Analysis and Metabolite Identification, in Sample Preparation for Hyphenated Analytical Techniques (ed J. M. Rosenfeld), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444305500.ch6

Editor Information

  1. Faculty of Health Science, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5

Author Information

  1. 1

    Physical Methods Section, MSD Neuroscience Research Centre, Eastwick Road, Harlow, Essex CM20 2QR, UK

  2. 2

    Drug Metabolism Section, MSD Neuroscience Research Centre, Eastwick Road, Harlow, Essex CM20 2QR, UK

  3. 3

    Automated MedChem Group, MSD Neuroscience Research Centre, Eastwick Road, Harlow, Essex CM20 2QR, UK

Publication History

  1. Published Online: 3 MAR 2009
  2. Published Print: 27 SEP 2004

ISBN Information

Print ISBN: 9781405111065

Online ISBN: 9781444305500

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CHAPTER TOOLS

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Keywords:

  • challenges associated with sample analysis in support of early drug discovery;
  • hyphenated techniques in drug discovery;
  • Supercritical fluid chromatography (SFC) - complementary separation technique;
  • evaporative light scattering detection (ELSD);
  • purification of reaction mixtures;
  • column considerations;
  • quantitative bioanalysis;
  • mass spectrometer robustness;
  • metabolite identification

Summary

This chapter contains sections titled:

  • Challenges associated with sample analysis and purification in support of early drug discovery

  • Quantitative bioanalysis

  • Metabolite identification

  • Conclusion

  • References

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