Chapter 9. Studies on Animal to Instrument Hyphenation: Development of Separation-Based Sensors for near Real-Time Monitoring of Drugs and Neurotransmitters

  1. J. M. Rosenfeld
  1. Malonne Davies,
  2. Bryan Huynh,
  3. Sara Logan,
  4. Kathleen Heppert and
  5. Susan Lunte

Published Online: 3 MAR 2009

DOI: 10.1002/9781444305500.ch9

Sample Preparation for Hyphenated Analytical Techniques

Sample Preparation for Hyphenated Analytical Techniques

How to Cite

Davies, M., Huynh, B., Logan, S., Heppert, K. and Lunte, S. (2009) Studies on Animal to Instrument Hyphenation: Development of Separation-Based Sensors for near Real-Time Monitoring of Drugs and Neurotransmitters, in Sample Preparation for Hyphenated Analytical Techniques (ed J. M. Rosenfeld), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444305500.ch9

Editor Information

  1. Faculty of Health Science, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5

Author Information

  1. Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA

Publication History

  1. Published Online: 3 MAR 2009
  2. Published Print: 27 SEP 2004

ISBN Information

Print ISBN: 9781405111065

Online ISBN: 9781444305500

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Keywords:

  • classical methods for sampling and analyzing blood and tissue;
  • animal to instrument hyphenation;
  • sample preparation for hyphenated analyses;
  • intact animal studies - anesthetized vs recovered;
  • classical methods of tissue sampling;
  • ultrafiltration (UF);
  • microdialysis sampling in live animal system;
  • analytical system detector output;
  • UF and automated blood sampling and removing fluids from animal;
  • coupling online sampling technique directly with separation methods

Summary

This chapter contains sections titled:

  • Introduction

  • Obtaining in vivo biological samples by classical techniques: limitations, challenges and other considerations

  • Modern in vivo sampling techniques

  • Analytical methodologies for online microdialysis sampling

  • Conclusions

  • Acknowledgements

  • References