Chapter 13. Blood Pressure and Cardiovascular Disease

  1. Salim Yusuf DPhil, FRCPC, FRSC Research Chair Professor of Medicine Director Vice President Research4,5,6,
  2. John A Cairns MD, FRCPC Professor of Medicine Former Dean7,
  3. A John Camm MD British Heart Foundation Professor Head of Cardiac8,
  4. Ernest L Fallen MD, FRCPC Professor Emeritus9 and
  5. Bernard J Gersh MB, ChB, DPhil Consultant Professor of Medicine10
  1. Curt D Furberg MD, PhD Professor1,
  2. Bruce M Psaty MD, PhD Professor2 and
  3. Elsayed Z Soliman MD, MSc, MS Associate Director Assistant Professor3

Published Online: 21 MAY 2010

DOI: 10.1002/9781444309768.ch13

Evidence-Based Cardiology, Third Edition

Evidence-Based Cardiology, Third Edition

How to Cite

Furberg, C. D., Psaty, B. M. and Soliman, E. Z. (2009) Blood Pressure and Cardiovascular Disease, in Evidence-Based Cardiology, Third Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309768.ch13

Editor Information

  1. 4

    McMaster University, Canada

  2. 5

    Population Health Research Institute, McMaster University, Hamilton Health Sciences, Canada

  3. 6

    Hamilton Health Sciences, Hamilton, Ontario, Canada

  4. 7

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

  5. 8

    St George's University of London, London, UK

  6. 9

    McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

  7. 10

    Mayo Clinic College of Medicine, Rochester, MN, USA

Author Information

  1. 1

    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  2. 2

    Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA

  3. 3

    Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Publication History

  1. Published Online: 21 MAY 2010
  2. Published Print: 13 NOV 2009

ISBN Information

Print ISBN: 9781405159258

Online ISBN: 9781444309768



  • hyperlipidemia;
  • coronary heart disease;
  • lipid lowering agents;
  • hypercholesterolemia;
  • hypertriglyceridemia;
  • statins;
  • dyslipidemia


This chapter reviews the evidence supporting the use of lipid lowering agents for the prevention of cardiovascular disease. Currently available agents are discussed relative to effects on lipid levels, their use in the clinic, and their effects upon clinical outcomes. The guidelines of the National Cholesterol Education Program are presented, and the rationale for their use is examined. The application of the guidelines to special populations such as the elderly, women, diabetics, and those with small dense LDL particles is summarized.