Chapter 18. Obesity

  1. Salim Yusuf DPhil, FRCPC, FRSC Research Chair Professor of Medicine Director Vice President Research4,5,6,
  2. John A Cairns MD, FRCPC Professor of Medicine Former Dean7,
  3. A John Camm MD British Heart Foundation Professor Head of Cardiac8,
  4. Ernest L Fallen MD, FRCPC Professor Emeritus9 and
  5. Bernard J Gersh MB, ChB, DPhil Consultant Professor of Medicine10
  1. Raj S Padwal MD, MSc, FRCPC Associate Professor1 and
  2. Arya M Sharma MD, PhD, FRCPC Professor of Medicine Chair2,3

Published Online: 21 MAY 2010

DOI: 10.1002/9781444309768.ch18

Evidence-Based Cardiology, Third Edition

Evidence-Based Cardiology, Third Edition

How to Cite

Padwal, R. S. and Sharma, A. M. (2009) Obesity, in Evidence-Based Cardiology, Third Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309768.ch18

Editor Information

  1. 4

    McMaster University, Canada

  2. 5

    Population Health Research Institute, McMaster University, Hamilton Health Sciences, Canada

  3. 6

    Hamilton Health Sciences, Hamilton, Ontario, Canada

  4. 7

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

  5. 8

    St George's University of London, London, UK

  6. 9

    McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

  7. 10

    Mayo Clinic College of Medicine, Rochester, MN, USA

Author Information

  1. 1

    Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, Canada

  2. 2

    Royal Alexandra Hospital, Edmonton, Alberta, Canada

  3. 3

    Obesity Management & Research, University of Alberta, Edmonton, Alberta, Canada

Publication History

  1. Published Online: 21 MAY 2010
  2. Published Print: 13 NOV 2009

ISBN Information

Print ISBN: 9781405159258

Online ISBN: 9781444309768



  • obesity - highly prevalent, complex chronic disease;
  • body mass index - correlation with excess body fat;
  • risk associated with obesity - type 2 diabetes;
  • achieving weight loss - diet, physical activity, behavior modification, pharmacotherapy;
  • goals of treatment - reducing body weight, maintaining weight loss and increasing quality of life;
  • antiobesity drug therapy - augmenting diet, physical activity and behavioral therapy;
  • drugs effecting secondary cardiovascular risk factors - orlistat, sibutramine, rimonabant


This chapter contains sections titled:

  • Introduction and historical perspective

  • Nomenclature and definitions

  • Incidence, natural history and prognosis

  • Pathophysiology

  • Management

  • Conclusion

  • References