Chapter 42. Syncope

  1. Salim Yusuf DPhil, FRCPC, FRSC Research Chair Professor of Medicine Director Vice President Research3,4,5,
  2. John A Cairns MD, FRCPC Professor of Medicine Former Dean6,
  3. A John Camm MD British Heart Foundation Professor Head of Cardiac7,
  4. Ernest L Fallen MD, FRCPC Professor Emeritus8 and
  5. Bernard J Gersh MB, ChB, DPhil Consultant Professor of Medicine9
  1. David G Benditt MD, FACC, FRCPC, FHRS Professor of Medicine Co-Director1,
  2. Fei Lu PhD, FACC, FHRS Associate Professor of Medicine Director2 and
  3. Scott Sakaguchi MD Associate Professor of Medicine1

Published Online: 21 MAY 2010

DOI: 10.1002/9781444309768.ch42

Evidence-Based Cardiology, Third Edition

Evidence-Based Cardiology, Third Edition

How to Cite

Benditt, D. G., Lu, F. and Sakaguchi, S. (2009) Syncope, in Evidence-Based Cardiology, Third Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309768.ch42

Editor Information

  1. 3

    McMaster University, Canada

  2. 4

    Population Health Research Institute, McMaster University, Hamilton Health Sciences, Canada

  3. 5

    Hamilton Health Sciences, Hamilton, Ontario, Canada

  4. 6

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

  5. 7

    St George's University of London, London, UK

  6. 8

    McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

  7. 9

    Mayo Clinic College of Medicine, Rochester, MN, USA

Author Information

  1. 1

    Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, MN, USA

  2. 2

    Cardiac Electrophysiology Laboratories, Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, MN, USA

Publication History

  1. Published Online: 21 MAY 2010
  2. Published Print: 13 NOV 2009

ISBN Information

Print ISBN: 9781405159258

Online ISBN: 9781444309768



  • syncope - transient loss of consciousness (TLOC);
  • nomenclature - distinguishing other forms of TLOC;
  • incidence, natural history and prognosis - increased primary diagnoses of “syncope and collapse”;
  • pathophysiology - upright position at onset of attack;
  • diagnosis - better understanding of improvement in syncope management practices;
  • treatment - effectiveness of syncope prevention depending upon diagnosis;
  • cost-effectiveness issues - lost productivity, economic derangement and loss of vocation


This chapter contains sections titled:

  • Introduction

  • Nomenclature

  • Incidence, natural history, and prognosis

  • Pathophysiology

  • Diagnosis

  • Treatment

  • Cost-effectiveness issues

  • Conclusion

  • References