Chapter 59. Infective Endocarditis

  1. Salim Yusuf DPhil, FRCPC, FRSC Research Chair Professor of Medicine Director Vice President Research3,4,5,
  2. John A Cairns MD, FRCPC Professor of Medicine Former Dean6,
  3. A John Camm MD British Heart Foundation Professor Head of Cardiac7,
  4. Ernest L Fallen MD, FRCPC Professor Emeritus8 and
  5. Bernard J Gersh MB, ChB, DPhil Consultant Professor of Medicine9
  1. Zainab Samad MD Fellow1 and
  2. Andrew Wang MD Associate Professor Director2

Published Online: 21 MAY 2010

DOI: 10.1002/9781444309768.ch59

Evidence-Based Cardiology, Third Edition

Evidence-Based Cardiology, Third Edition

How to Cite

Samad, Z. and Wang, A. (2009) Infective Endocarditis, in Evidence-Based Cardiology, Third Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309768.ch59

Editor Information

  1. 3

    McMaster University, Canada

  2. 4

    Population Health Research Institute, McMaster University, Hamilton Health Sciences, Canada

  3. 5

    Hamilton Health Sciences, Hamilton, Ontario, Canada

  4. 6

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

  5. 7

    St George's University of London, London, UK

  6. 8

    McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

  7. 9

    Mayo Clinic College of Medicine, Rochester, MN, USA

Author Information

  1. 1

    Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA

  2. 2

    Cardiovascular Disease Fellowship Program, Duke University Medical Center, Durham, NC, USA

Publication History

  1. Published Online: 21 MAY 2010
  2. Published Print: 13 NOV 2009

ISBN Information

Print ISBN: 9781405159258

Online ISBN: 9781444309768



  • infective endocarditis (IE) - heart valves and endocardial microbial infection;
  • acute or subacute IE;
  • IE incidence and epidemiology;
  • IE pathogenesis - IE development host factor - congenital heart disease;
  • IE diagnosis - blood cultures and electrocardiography;
  • IE diagnostic criteria - modified Duke criteria;
  • IE treatment - antibiotic therapy and surgical treatment;
  • prosthetic valve endocarditis (PVE) prognostic factors


This chapter contains sections titled:

  • Introduction and historical perspective

  • Nomenclature

  • Incidence and epidemiology

  • Pathogenesis

  • Diagnosis

  • Treatment

  • Complications and outcome

  • Prevention

  • References