Chapter 60. Antithrombotic Therapy after Heart Valve Replacement

  1. Salim Yusuf DPhil, FRCPC, FRSC Research Chair Professor of Medicine Director Vice President Research3,4,5,
  2. John A Cairns MD, FRCPC Professor of Medicine Former Dean6,
  3. A John Camm MD British Heart Foundation Professor Head of Cardiac7,
  4. Ernest L Fallen MD, FRCPC Professor Emeritus8 and
  5. Bernard J Gersh MB, ChB, DPhil Consultant Professor of Medicine9
  1. Jack C J Sun MD, MSc1 and
  2. John W Eikelboom MBBS, MSc, FRACP, FRCPA, FRCPC Associate Professor2

Published Online: 21 MAY 2010

DOI: 10.1002/9781444309768.ch60

Evidence-Based Cardiology, Third Edition

Evidence-Based Cardiology, Third Edition

How to Cite

Sun, J. C. J. and Eikelboom, J. W. (2009) Antithrombotic Therapy after Heart Valve Replacement, in Evidence-Based Cardiology, Third Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309768.ch60

Editor Information

  1. 3

    McMaster University, Canada

  2. 4

    Population Health Research Institute, McMaster University, Hamilton Health Sciences, Canada

  3. 5

    Hamilton Health Sciences, Hamilton, Ontario, Canada

  4. 6

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

  5. 7

    St George's University of London, London, UK

  6. 8

    McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

  7. 9

    Mayo Clinic College of Medicine, Rochester, MN, USA

Author Information

  1. 1

    Division of Cardiac Surgery, McMaster University, Hamilton, Ontario, Canada

  2. 2

    Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Publication History

  1. Published Online: 21 MAY 2010
  2. Published Print: 13 NOV 2009

ISBN Information

Print ISBN: 9781405159258

Online ISBN: 9781444309768



  • antithrombotic therapy after heart valve replacement;
  • mechanical valves - in preventing thrombus formation on valve surfaces;
  • caged-ball valves associated thromboemobilism;
  • bioprosthetic valves - porcine and pericardial valves;
  • oral anticoagulants - vitamin K antagonists (VKAs) - anticoagulant therapy;
  • thromboembolism - after bioprosthetic valve replacement;
  • prosthetic heart valves thrombogenecity factors - altered blood flow


This chapter contains sections titled:

  • Introduction and historical perspective

  • Nomenclature and definitions

  • Incidence, natural history and prognosis

  • Pathophysiology

  • Antithrombotic therapy

  • Conclusion

  • References