Chapter One. The Normal Bone Marrow

  1. Barbara J. Bain MBBS, FRACP, FRCPath Professor of Diagnostic Haematology Honorary Consultant Haematologist1,2,
  2. David M. Clark MD, MRCP (UK), FRCPath Consultant Histopathologist Honorary Consultant Histopathologist Special Lecturer in Pathology3,4,5 and
  3. Bridget S. Wilkins DM, PhD, FRCPath Consultant in Haematopathology Honorary Senior Lecturer6,7

Published Online: 26 NOV 2009

DOI: 10.1002/9781444309782.ch1

Bone Marrow Pathology, Fourth Edition

Bone Marrow Pathology, Fourth Edition

How to Cite

Bain, B. J., Clark, D. M. and Wilkins, B. S. (2009) The Normal Bone Marrow, in Bone Marrow Pathology, Fourth Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309782.ch1

Author Information

  1. 1

    St Mary's Hospital Campus of Imperial College Faculty of Medicine, Imperial College, London, UK

  2. 2

    St Mary's Hospital, London UK

  3. 3

    Path Links, North Lincolnshire and Goole Hospitals NHS Foundation Trust, UK

  4. 4

    Nottingham University Hospitals NHS Trust, Nottingham, UK

  5. 5

    University of Nottingham, UK

  6. 6

    Guy's and St Thomas' Hospitals NHS Foundation Trust, London, UK

  7. 7

    King's College, London, UK

Publication History

  1. Published Online: 26 NOV 2009
  2. Published Print: 19 DEC 2009

ISBN Information

Print ISBN: 9781405168250

Online ISBN: 9781444309782



  • normal bone marrow;
  • haemopoietic marrow distribution;
  • bone marrow organization;
  • haemopoietic cells of bone marrow - embedded in connective tissue stroma;
  • bone marrow aspiration;
  • trephine biopsy of bone marrow;
  • ethylene diamine tetra-acetic acid (EDTA);
  • bone marrow aspiration and trephine biopsy - advantages and limitations;
  • bone marrow cellular composition;
  • lymphopoiesis - bone marrow containing cells of T- and B-lymphoid lineages


This chapter contains sections titled:

  • The distribution of haemopoietic marrow

  • The organization of the bone marrow

  • Examination of the bone marrow

  • Cellularity

  • Haemopoietic cells

  • Osteoblasts and osteoclasts

  • Lymphopoiesis

  • The cellular composition of bone marrow

  • Interpretation of bone marrow aspirates and trephine biopsies

  • Artefacts

  • References