Chapter Three. Infection and Reactive Changes

  1. Barbara J. Bain MBBS, FRACP, FRCPath Professor of Diagnostic Haematology Honorary Consultant Haematologist1,2,
  2. David M. Clark MD, MRCP (UK), FRCPath Consultant Histopathologist Honorary Consultant Histopathologist Special Lecturer in Pathology3,4,5 and
  3. Bridget S. Wilkins DM, PhD, FRCPath Consultant in Haematopathology Honorary Senior Lecturer6,7

Published Online: 26 NOV 2009

DOI: 10.1002/9781444309782.ch3

Bone Marrow Pathology, Fourth Edition

Bone Marrow Pathology, Fourth Edition

How to Cite

Bain, B. J., Clark, D. M. and Wilkins, B. S. (2009) Infection and Reactive Changes, in Bone Marrow Pathology, Fourth Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444309782.ch3

Author Information

  1. 1

    St Mary's Hospital Campus of Imperial College Faculty of Medicine, Imperial College, London, UK

  2. 2

    St Mary's Hospital, London UK

  3. 3

    Path Links, North Lincolnshire and Goole Hospitals NHS Foundation Trust, UK

  4. 4

    Nottingham University Hospitals NHS Trust, Nottingham, UK

  5. 5

    University of Nottingham, UK

  6. 6

    Guy's and St Thomas' Hospitals NHS Foundation Trust, London, UK

  7. 7

    King's College, London, UK

Publication History

  1. Published Online: 26 NOV 2009
  2. Published Print: 19 DEC 2009

ISBN Information

Print ISBN: 9781405168250

Online ISBN: 9781444309782



  • bone marrow infection and reactive changes and nature and chronicity of infection;
  • bacterial and rickettsial infection;
  • bone marrow cytology;
  • PAS-positive macrophages and intra- and extracellular PAS-positive bacillary bodies;
  • acute myeloid leukaemia (AML) or chronic myelomonocytic leukaemia (CMML);
  • virus-induced haemophagocytic syndrome - confused with malignant histiocytosis;
  • parasitic diseases;
  • bone marrow granulomas;
  • bone marrow fibrosis - reticulin or reticulin and collagen increase in bone marrow;
  • HIV infection and acquired immune deficiency syndrome


This chapter contains sections titled:

  • Infection

  • Bone marrow granulomas

  • Reactive lymphoid aggregates and polymorphous lymphoid hyperplasia

  • Plasmacytosis and cytological abnormalities in plasma cells

  • Mast cells

  • Histiocytosis

  • Haemophagocytic syndromes

  • Iron overload

  • HIV infection and the acquired immune deficiency syndrome

  • Bone marrow necrosis

  • Gelatinous transformation

  • Amyloid deposition

  • Bone marrow fibrosis

  • References