Chapter 6. Randomisation

  1. Allan Hackshaw Deputy Director1,2

Published Online: 29 APR 2009

DOI: 10.1002/9781444311723.ch6

A Concise Guide to Clinical Trials

A Concise Guide to Clinical Trials

How to Cite

Hackshaw, A. (2009) Randomisation, in A Concise Guide to Clinical Trials, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311723.ch6

Author Information

  1. 1

    Cancer Research, UK

  2. 2

    UCL Cancer Trials Centre, UK

Publication History

  1. Published Online: 29 APR 2009
  2. Published Print: 10 APR 2009

ISBN Information

Print ISBN: 9781405167741

Online ISBN: 9781444311723

SEARCH

Keywords:

  • Randomisation – produces treatment groups that have similar characteristics;
  • Simple randomisation – produce similarly sized groups;
  • Stratified randomisation – a good way of balancing important prognostic factors;
  • double-blind treatment trial;
  • Minimisation – aims to ensure balance between treatment groups for pre-specified prognostic factors;
  • multi-variate methods

Summary

This chapter contains sections titled:

  • Simple randomisation

  • Stratified randomisation

  • Minimisation

  • Unequal randomisation

  • Which method of randomisation to use?

  • Eligibility

  • Randomising in practice

  • Checking that the randomisation process worked: examining baseline characteristics

  • Summary

  • References