Chapter 10. Transfusion-Related Immunomodulation

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist4,5 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader6,7
  1. Morris A. Blajchman MD, FRCP (C) Professor Emeritus Medical Director1,2 and
  2. Eleftherios C. Vamvakas MD, PhD Professor Vice-Chair Director3

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch10

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Blajchman, M. A. and Vamvakas, E. C. (2009) Transfusion-Related Immunomodulation, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch10

Editor Information

  1. 4

    University of Oxford, Oxford, UK

  2. 5

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 6

    NHS Blood and Transplant, Bristol, UK

  4. 7

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. 1

    Departments of Pathology and Medicine, McMaster University, Hamilton, Ontario, Canada

  2. 2

    Canadian Blood Services, Hamilton, Ontario, Canada

  3. 3

    Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • transfusion-related immunomodulation;
  • allogeneic blood transfusion (ABT);
  • transfusion-related immunomodulation (TRIM);
  • buffy-coat-reduced RBCs;
  • TRIM effects mediated by AMCs;
  • tissue injury;
  • pro-inflammatory;
  • post-storage filtration;
  • WBC-reduced allogeneic whole blood


This chapter contains sections titled:

  • Clinical studies of adverse TRIM effects

  • TRIM effects mediated by AMCs

  • TRIM effects mediated by WBC-derived soluble mediators

  • TRIM effects mediated by soluble molecules circulating in allogeneic plasma

  • Association between non-WBC-reduced ABT and short-term mortality

  • Conclusions

  • Key points

  • Further reading