Chapter 14. Bacterial Contamination

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist3,4 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader5,6
  1. Patricia E. Hewitt FRCP, FRCPath Consultant Specialist1,2

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch14

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Hewitt, P. E. (2009) Bacterial Contamination, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch14

Editor Information

  1. 3

    University of Oxford, Oxford, UK

  2. 4

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 5

    NHS Blood and Transplant, Bristol, UK

  4. 6

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. 1

    NHS Blood and Transplant, London, UK

  2. 2

    University Hospitals Bristol, NHS Foundation Trust Bristol, UK

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • transfusion-transmitted viral infection;
  • chemotherapy;
  • non-pathogenic bacteria;
  • donor bacteraemia;
  • blood collection;
  • storage temperature of platelets;
  • BacT/alert system;
  • phagocytosis;
  • photodynamic methods for inactivation of bacteria


This chapter contains sections titled:

  • Incidence of bacterial contamination

  • Possible explanations for apparent infrequency of clinical events

  • Factors contributing to frequency of bacterial contamination of platelets

  • Types of bacterial contaminantsSources of bacterial contamination

  • Clinical features of bacterial contamination

  • Immediate management

  • Investigations

  • Measures to reduce the risk of bacterial contamination

  • Summary

  • Key points

  • Further reading