Chapter 15. Variant Creutzfeldt–Jakob Disease

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist2,3 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader4,5
  1. Marc L. Turner MB, ChB, MBA, PhD, FRCP, FRCPath Professor Clinical Director

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch15

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Turner, M. L. (2009) Variant Creutzfeldt–Jakob Disease, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch15

Editor Information

  1. 2

    University of Oxford, Oxford, UK

  2. 3

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 4

    NHS Blood and Transplant, Bristol, UK

  4. 5

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. Edinburgh Blood Transfusion Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • scrapie – an endemic disease of sheep and goats;
  • Creutzfeldt–Jakob disease (CJD);
  • peripheral transmission;
  • prion hypothesis;
  • erythyroid differentiation associated factors (EDAF);
  • universal leucocyte reduction;
  • cell, tissue and organ transplantation


This chapter contains sections titled:

  • Variant CJD

  • Aetiology and pathophysiology

  • Assessing peripheral blood infectivity in animal models

  • Clinical transmission of CJD from the peripheral blood of patients

  • Strategies for risk containment

  • Donor selection

  • Importation of blood components

  • Development of peripheral blood assays for donor screening

  • Component processing

  • Plasma products

  • Optimal use of blood components

  • Cell, tissue and organ transplantation

  • Key points

  • Further reading