Chapter 30. Inherited and Acquired Coagulation Disorders

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist3,4 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader5,6
  1. Vickie McDonald MA, MRCP, FRCPath Clinical Research Fellow1,
  2. J. Kim Ryland BSc, MRCP, DipRCPath Clinical Research Fellow1,
  3. Joanne E. Joseph MD, FRACP, FRCP2 and
  4. Samuel J. Machin MD, FRCP, FRCPath Professor1

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch30

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

McDonald, V., Ryland, J. K., Joseph, J. E. and Machin, S. J. (2009) Inherited and Acquired Coagulation Disorders, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch30

Editor Information

  1. 3

    University of Oxford, Oxford, UK

  2. 4

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 5

    NHS Blood and Transplant, Bristol, UK

  4. 6

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. 1

    Haemostasis Research Unit, Department of Haematology, University College London, London, UK

  2. 2

    Department of Haematology and Stem Cell Transplantation, St Vincent's Hospital, Darlinghurst, New South Wales, Australia

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • procoagulant cascade;
  • tissue factor (TF);
  • haemostatic defect;
  • disseminated intravascular coagulation (DIC);
  • microthrombus formation;
  • coagulopathy;
  • uraemia;
  • tranexamic acid;
  • von Willebrand disease (vWD)


This chapter contains sections titled:

  • Normal haemostasis

  • Investigation of abnormal haemostasis

  • Transfusion support for patients with acquired haemostatic defects

  • Transfusion support for patients with inherited haemostatic defects

  • Appropriate and inappropriate use of FFP, cryoprecipitate and coagulation factor concentrates

  • Key points

  • Further reading