Chapter 32. Immunodeficiency and Immunoglobulin Therapy

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist2,3 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader4,5
  1. Siraj A. Misbah MSc, FRCP, FRCPath Consultant Clinical Immunologist Honorary Senior Clinical Lecturer

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch32

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Misbah, S. A. (2009) Immunodeficiency and Immunoglobulin Therapy, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch32

Editor Information

  1. 2

    University of Oxford, Oxford, UK

  2. 3

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 4

    NHS Blood and Transplant, Bristol, UK

  4. 5

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. Oxford Radcliffe Hospitals, University of Oxford, Oxford, UK

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • immunodeficiency and immunoglobulin therapy;
  • immunodeficiency disease;
  • B-cell function;
  • hypogammaglobulinaemia;
  • Addison's disease;
  • X-linked agammaglobulinaemia (XLA);
  • haemopoietic stem cell transplantation (HSCT);
  • gene therapy;
  • vaccine-associated disease


This chapter contains sections titled:

  • Immunodeficiency and immunoglobulin therapy

  • Primary immunodeficiency disorders

  • Predominant B-cell deficiency disorders

  • X-linked agammaglobulinaemia

  • Severe combined immunodeficiency

  • Adverse effects of intravenous immunoglobulin therapy

  • Risks of viral transmission

  • Practical aspects of immunoglobulin therapy - product selection and safe use

  • Key points

  • Further reading