Chapter 42. Recent Advances in Clinical Cellular Immunotherapy

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist4,5 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader6,7
  1. Mark W. Lowdell MSc, PhD, FRCPath, MICR Senior Lecturer in Haematology Honorary Consultant Immunologist1,2 and
  2. Emma Morris MA, PhD, MRCP, MRCPath Senior Lecturer in Immunotherapy Honorary Consultant Haematologist3

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch42

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Lowdell, M. W. and Morris, E. (2009) Recent Advances in Clinical Cellular Immunotherapy, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch42

Editor Information

  1. 4

    University of Oxford, Oxford, UK

  2. 5

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 6

    NHS Blood and Transplant, Bristol, UK

  4. 7

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. 1

    University College London Medical School, London, UK

  2. 2

    Royal Free Hospital, London, UK

  3. 3

    Department of Immunology and Molecular, Pathology, University College London Medical School, Haematologist (BMT), University College London Hospitals NHS Trust, London, UK

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761

SEARCH

Keywords:

  • passive immunotherapy;
  • anti-leukaemic activity;
  • ex vivo stimulation of allogeneic donor T cells;
  • immunomagnetic selection;
  • T-cell receptor (TCR) gene transfer;
  • ex vivo activated NK cells;
  • haploidentical HPC transplantation;
  • good manufacturing practice (GMP);
  • CE-marked clinical grade immunomagnetic cell sorters

Summary

This chapter contains sections titled:

  • Introduction

  • Cellular immunotherapy in haemopoietic progenitor cell transplantation

  • Non-specific T-cell immunotherapy

  • Tumour-specific or tumour-restricted T-cell immunotherapy

  • Tumour-restricted natural killer cell immunotherapy

  • Passive cellular immunotherapy of infectious disease

  • Technical advances facilitating translational research in cellular immunotherapy

  • Key points

  • Further reading