Chapter 8. Febrile and Allergic Transfusion Reactions

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist3,4 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader5,6
  1. Cynthia Wu MD, FRCPC Fellow1 and
  2. Nancy M. Heddle MSc, FCSMLS (D) Associate Professor Adjunct Scientist1,2

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch8

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Wu, C. and Heddle, N. M. (2009) Febrile and Allergic Transfusion Reactions, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch8

Editor Information

  1. 3

    University of Oxford, Oxford, UK

  2. 4

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 5

    NHS Blood and Transplant, Bristol, UK

  4. 6

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. 1

    Department of Medicine, McMaster University, Hamilton, Ontario, Canada

  2. 2

    Canadian Blood Services, Hamilton, Ontario, Canada

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • febrile and allergic transfusion reactions;
  • febrile non-haemolytic transfusion reactions (FNHTRs);
  • leucocyte-reduced blood platelets;
  • platelet-derived cytokines;
  • leucocyte antigen–antibody mechanism;
  • leucocyte-derived cytokine accumulation;
  • allergic transfusion reaction;
  • premedication with antipyretics;
  • leucocyte reduction


This chapter contains sections titled:

  • Febrile non-haemolytic transfusion reactions

  • Allergic transfusion reactions

  • Key points

  • Further reading