Chapter 9. Transfusion-Related Acute Lung Injury

  1. Michael F. Murphy MD, FRCP, FRCPath Professor Consultant Haematologist3,4 and
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath Consultant Haematologist Honorary Clinical Reader5,6
  1. Steven H. Kleinman MD Clinical Professor1 and
  2. Ram Kakaiya MD Medical Director2

Published Online: 5 MAY 2009

DOI: 10.1002/9781444311761.ch9

Practical Transfusion Medicine, Third Edition

Practical Transfusion Medicine, Third Edition

How to Cite

Kleinman, S. H. and Kakaiya, R. (2009) Transfusion-Related Acute Lung Injury, in Practical Transfusion Medicine, Third Edition (eds M. F. Murphy and D. H. Pamphilon), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311761.ch9

Editor Information

  1. 3

    University of Oxford, Oxford, UK

  2. 4

    NHS Blood and Transplant and Department of Haematology, John Radcliffe Hospital, Oxford, UK

  3. 5

    NHS Blood and Transplant, Bristol, UK

  4. 6

    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Author Information

  1. 1

    University of British Columbia, Victoria, British Columbia, Canada

  2. 2

    LifeSource Blood Services, Glenview, Illinois, USA

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 14 APR 2009

ISBN Information

Print ISBN: 9781405181969

Online ISBN: 9781444311761



  • transfusion-related acute lung injury;
  • oxygen desaturation and bilateral lung infiltrates;
  • pulmonary dysfunction;
  • acute lung injury (ALI);
  • antibody-mediated mechanisms and non-antibody-mediated mechanisms;
  • diagnosis of TRALI;
  • anaphylactic reaction;
  • transfusion associated dyspnoea (TAD);
  • diuretics


This chapter contains sections titled:

  • Definition

  • Incidence

  • Clinical manifestations

  • Types of blood components that can cause TRALI

  • Pathogenesis

  • Lung histology

  • Differential diagnosis

  • Management

  • Outcome and morbidity

  • Prevention

  • Key points

  • Further reading