Chapter 10. Genetics of Atherosclerosis

  1. Dan Roden MD Professor Director Assistant Vice-Chancellor
  1. Robert Roberts MD, FRCPC, FACC President CEO1,
  2. Ruth McPherson MD, PhD, FRCPC Director2 and
  3. Alexandre F. R. Stewart BScH, MSc, PhD Principal Investigator3

Published Online: 27 APR 2009

DOI: 10.1002/9781444311785.ch10

Cardiovascular Genetics and Genomics

Cardiovascular Genetics and Genomics

How to Cite

Roberts, R., McPherson, R. and Stewart, A. F. R. (2009) Genetics of Atherosclerosis, in Cardiovascular Genetics and Genomics (ed D. Roden), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311785.ch10

Editor Information

  1. Oates Institute for Experimental Therapeutics, Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

Author Information

  1. 1

    University of Ottawa Heart Institute, Ottawa, Ontario, Canada

  2. 2

    Lipid Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

  3. 3

    The Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Publication History

  1. Published Online: 27 APR 2009
  2. Published Print: 17 APR 2009

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman

ISBN Information

Print ISBN: 9781405175401

Online ISBN: 9781444311785



  • coronary heart disease (CAD);
  • gene identification;
  • high-density lipoprotein (HDL);
  • single nucleotide polymorphism (SNP);
  • mapping genes;
  • replication;
  • documented myocardial infarction


This chapter contains sections titled:

  • Prevalence and importance of atherosclerosis

  • Gene identification, a prerequisite for comprehensive prevention and treatment in the era of personalized medicine

  • Evidence for genetic predisposition

  • Obstacles in the identification of genes for atherosclerosis

  • The candidate gene approach and its lack of success

  • Genome–wide case–control association studies: an idea whose time has come

  • Genome-wide association studies: current progress

  • Phenotyping coronary artery disease cases and controls

  • Gene to gene interactions and their interaction with the environment

  • Personalized medicine: a new paradigm for prevention and treatment

  • References