Chapter 13. Genetic Determinants of Arterial Thrombosis

  1. Dan Roden MD Professor Director Assistant Vice-Chancellor
  1. Yasmin Khan MD1,
  2. Nauder Faraday MD Associate Professor Director2,
  3. William Herzog MD Assistant professor3 and
  4. Alan R. Shuldiner MD Director Head4

Published Online: 27 APR 2009

DOI: 10.1002/9781444311785.ch13

Cardiovascular Genetics and Genomics

Cardiovascular Genetics and Genomics

How to Cite

Khan, Y., Faraday, N., Herzog, W. and Shuldiner, A. R. (2009) Genetic Determinants of Arterial Thrombosis, in Cardiovascular Genetics and Genomics (ed D. Roden), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311785.ch13

Editor Information

  1. Oates Institute for Experimental Therapeutics, Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

Author Information

  1. 1

    Maryland Endocrine, P.A., Columbia, MD, USA

  2. 2

    Perioperative Hemostasis and Thrombosis Research Laboratory, Perioperative Gonomic Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

  3. 3

    Johns Hopkins University School of Medicine, Baltimore, MD, USA

  4. 4

    John A. Whitehurst Professor of Medicine, Program in Genetics and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA

Publication History

  1. Published Online: 27 APR 2009
  2. Published Print: 17 APR 2009

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman

ISBN Information

Print ISBN: 9781405175401

Online ISBN: 9781444311785



  • low-flow venous system;
  • high-flow arterial system;
  • platelets;
  • epinephrine-induced platelet aggregation;
  • arterial thrombosis;
  • platelet glycoproteins;
  • fibrinogen;
  • plasminogen activator inhibitor 1


This chapter contains sections titled:

  • Introduction

  • Mechanisms of arterial thrombosis: insights into candidate genes

  • Methods for quantifying platelet function

  • Evidence for a heritable component to platelet function and arterial thrombosis

  • Approaches to genetic analysis of arterial thrombosis and platelet function

  • Platelet glycoproteins

  • Soluble factors

  • The endothelium, nitric oxide, and nitric oxide synthase

  • Summary and future directions

  • References