Chapter 15. Case Study: Warfarin Pharmacogenetics from Single to Multiple Genes

  1. Dan Roden MD Professor Director Assistant Vice-Chancellor
  1. Michael D. Caldwell MD, PhD1 and
  2. Richard Berg MS2

Published Online: 27 APR 2009

DOI: 10.1002/9781444311785.ch15

Cardiovascular Genetics and Genomics

Cardiovascular Genetics and Genomics

How to Cite

Caldwell, M. D. and Berg, R. (2009) Case Study: Warfarin Pharmacogenetics from Single to Multiple Genes, in Cardiovascular Genetics and Genomics (ed D. Roden), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444311785.ch15

Editor Information

  1. Oates Institute for Experimental Therapeutics, Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

Author Information

  1. 1

    Department of Surgery, Marshfield Clinic, Marshfield, WI, USA

  2. 2

    Department of Biostatistics, Marshfield Clinic Research Foundation, Marshfield, WI, USA

Publication History

  1. Published Online: 27 APR 2009
  2. Published Print: 17 APR 2009

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman

ISBN Information

Print ISBN: 9781405175401

Online ISBN: 9781444311785



  • intracerebral hemorrhage;
  • vitamin K quinone;
  • warfarin pharmacokinetics;
  • xenobiotic metabolism;
  • warfarin therapy;
  • split-sample technique;
  • international warfarin pharmacogenetic consortium (IWPC)


This chapter contains sections titled:

  • Introduction

  • Pharmacodynamics of warfarin

  • Warfarin pharmacokinetics

  • Current knowledge in warfarin pharmacogenetics: the multigenetic regulation of warfarin action

  • Predictive models for warfarin therapy

  • Acknowledgments

  • References