Chapter 11. Therapies for the Allosensitized Patient

  1. Richard N. Fine MD Dean Distinguished Professor of Pediatrics3,
  2. Steven A. Webber MBChB, MRCP Professor of Pediatrics4,
  3. Kim M. Olthoff MD, FACS Associate Professor of Surgery Director5,
  4. Deirdre A. Kelly MD, FRCPI, FRCP, FRCPCH Professor of Paediatric Hepatology6 and
  5. William E. Harmon MD Professor of Pediatrics7
  1. Alice Peng MD Associate Director1 and
  2. Stanley C. Jordan MD Medical Director Professor of Pediatrics and Medicine1,2

Published Online: 5 MAY 2009

DOI: 10.1002/9781444312720.ch11

Pediatric Solid Organ Transplantation, Second Edition

Pediatric Solid Organ Transplantation, Second Edition

How to Cite

Peng, A. and Jordan, S. C. (2007) Therapies for the Allosensitized Patient, in Pediatric Solid Organ Transplantation, Second Edition (eds R. N. Fine, S. A. Webber, K. M. Olthoff, D. A. Kelly and W. E. Harmon), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444312720.ch11

Editor Information

  1. 3

    Stony Brook University School of Medicine, Stony Brook, New York 11794-8111, USA

  2. 4

    University of Pittsburgh School of Medicine, Division of Cardiology, Children's Hospital, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA

  3. 5

    Liver Transplant Program, University of Pennsylvania and the Children's Hospital of Philadelphia, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104, USA

  4. 6

    The Liver Unit, Birmingham Children's Hospital NHS Trust, Steelhouse Lane, Birmingham, B4 6NH, UK

  5. 7

    Division of Nephrology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Hunn-319, Boston, MA 02115, USA

Author Information

  1. 1

    Kidney Transplantation and Transplant Immunology, Center for Kidney Diseases and Transplantation, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA

  2. 2

    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 24 JAN 2007

ISBN Information

Print ISBN: 9781405124072

Online ISBN: 9781444312720



  • antihuman leukocyte antigen antibodies;
  • non-self HLA antigens;
  • antibody-mediated rejection (AMR);
  • intravenous immunoglobulin (IVIG) products;
  • IVIG infusion;
  • end-stage renal disease (ESRD) patients;
  • CMV hyperimmune globulin;
  • rituximab;
  • development of anti-HLA antibodies (DSA)


This chapter contains sections titled:

  • Cedars-Sinai Protocol

  • Johns Hopkins Protocol

  • Newer Therapies

  • Antibody-Mediated Rejection

  • Treatment of AMR with High-Dose IVIG: The Cedars-Sinai Experience

  • Use of Plasmapheresis and IVIG (or CMVIG) for Treatment of AMR

  • Use of Anti-CD20 Monoclonal Antibody in Treatment of AMR

  • Non-HLA Antibody-Mediated Rejection

  • Conclusions

  • References