Chapter 2. Allorecognition Pathways

  1. Richard N. Fine MD Dean Distinguished Professor of Pediatrics2,
  2. Steven A. Webber MBChB, MRCP Professor of Pediatrics3,
  3. Kim M. Olthoff MD, FACS Associate Professor of Surgery Director4,
  4. Deirdre A. Kelly MD, FRCPI, FRCP, FRCPCH Professor of Paediatric Hepatology5 and
  5. William E. Harmon MD Professor of Pediatrics6
  1. Nader Najafian MD Assistant Professor of Medicine and
  2. Mohamed H. Sayegh MD Professor of Medicine and Pediatrics

Published Online: 5 MAY 2009

DOI: 10.1002/9781444312720.ch2

Pediatric Solid Organ Transplantation, Second Edition

Pediatric Solid Organ Transplantation, Second Edition

How to Cite

Najafian, N. and Sayegh, M. H. (2007) Allorecognition Pathways, in Pediatric Solid Organ Transplantation, Second Edition (eds R. N. Fine, S. A. Webber, K. M. Olthoff, D. A. Kelly and W. E. Harmon), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444312720.ch2

Editor Information

  1. 2

    Stony Brook University School of Medicine, Stony Brook, New York 11794-8111, USA

  2. 3

    University of Pittsburgh School of Medicine, Division of Cardiology, Children's Hospital, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA

  3. 4

    Liver Transplant Program, University of Pennsylvania and the Children's Hospital of Philadelphia, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104, USA

  4. 5

    The Liver Unit, Birmingham Children's Hospital NHS Trust, Steelhouse Lane, Birmingham, B4 6NH, UK

  5. 6

    Division of Nephrology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Hunn-319, Boston, MA 02115, USA

Author Information

  1. Transplantation Research Center, Brigham and Women's Hospital, Children Hospital Boston, Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 24 JAN 2007

ISBN Information

Print ISBN: 9781405124072

Online ISBN: 9781444312720



  • allorecognition pathways;
  • T-cell-dependent process;
  • T-cell allorecognition;
  • tolerance-inducing strategies;
  • alloreactive T cells;
  • determinant frequency theory;
  • T-cell receptor;
  • MHC–peptide complex;
  • cross-reactive allorecognition


This chapter contains sections titled:

  • Direct Pathway of Allorecognition

  • Structure of the MHC Molecule and Allorecognition

  • Role of Endogenous Peptides in Allorecognition

  • Indirect Pathway of Allorecognition

  • Indirect Allorecognition and Chronic Rejection

  • Endothelial Cells and Allorecognition

  • Site of Allorecognition

  • Role of Allorecognition in the Effector Phase of Allograft Rejection

  • Allorecognition Pathways and the Induction of Tolerance

  • Conclusions

  • References