Chapter 5. Gene Polymorphisms and Pharmacogenomics

  1. Richard N. Fine MD Dean Distinguished Professor of Pediatrics4,
  2. Steven A. Webber MBChB, MRCP Professor of Pediatrics5,
  3. Kim M. Olthoff MD, FACS Associate Professor of Surgery Director6,
  4. Deirdre A. Kelly MD, FRCPI, FRCP, FRCPCH Professor of Paediatric Hepatology7 and
  5. William E. Harmon MD Professor of Pediatrics8
  1. Robyn Temple-Smolkin PhD Postdoctoral Associate1,
  2. Gilbert J. Burckart PharmD Professor Chairman Director2 and
  3. Adriana Zeevi PhD Professor of Pathology and Surgery Director3

Published Online: 5 MAY 2009

DOI: 10.1002/9781444312720.ch5

Pediatric Solid Organ Transplantation, Second Edition

Pediatric Solid Organ Transplantation, Second Edition

How to Cite

Temple-Smolkin, R., Burckart, G. J. and Zeevi, A. (2007) Gene Polymorphisms and Pharmacogenomics, in Pediatric Solid Organ Transplantation, Second Edition (eds R. N. Fine, S. A. Webber, K. M. Olthoff, D. A. Kelly and W. E. Harmon), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444312720.ch5

Editor Information

  1. 4

    Stony Brook University School of Medicine, Stony Brook, New York 11794-8111, USA

  2. 5

    University of Pittsburgh School of Medicine, Division of Cardiology, Children's Hospital, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA

  3. 6

    Liver Transplant Program, University of Pennsylvania and the Children's Hospital of Philadelphia, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104, USA

  4. 7

    The Liver Unit, Birmingham Children's Hospital NHS Trust, Steelhouse Lane, Birmingham, B4 6NH, UK

  5. 8

    Division of Nephrology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Hunn-319, Boston, MA 02115, USA

Author Information

  1. 1

    University of Pittsburgh Medical Center, Pittsburgh, PA, USA

  2. 2

    Department of Pharmacy, Clinical Pharmacogenomics Laboratory, University of Southern California, Los Angeles, CA, USA

  3. 3

    Histocompatibility and Immunogenetics, Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 24 JAN 2007

ISBN Information

Print ISBN: 9781405124072

Online ISBN: 9781444312720



  • pediatric transplant patients;
  • genetic polymorphisms;
  • single nucleotide base pair changes (SNP);
  • cytokine production;
  • proinflammatory cytokines;
  • graft dysfunction;
  • low proinflammatory cytokine genotype;
  • transplant coronary artery disease (TCAD);
  • pharmacologic and toxicologic effects


This chapter contains sections titled:

  • Gene Polymorphisms

  • Acute Allograft Rejection and Graft Function

  • Chronic Allograft Rejection

  • Infectious Complications

  • Pharmacogenetics and Transplantation

  • Conclusions

  • References