Chapter 7. Tolerance: A Review of Its Mechanisms in the Transplant Setting

  1. Richard N. Fine MD Dean Distinguished Professor of Pediatrics2,
  2. Steven A. Webber MBChB, MRCP Professor of Pediatrics3,
  3. Kim M. Olthoff MD, FACS Associate Professor of Surgery Director4,
  4. Deirdre A. Kelly MD, FRCPI, FRCP, FRCPCH Professor of Paediatric Hepatology5 and
  5. William E. Harmon MD Professor of Pediatrics6
  1. Alan D. Salama PhD, MRCP Senior Lecturer Honorary Consultant Physician

Published Online: 5 MAY 2009

DOI: 10.1002/9781444312720.ch7

Pediatric Solid Organ Transplantation, Second Edition

Pediatric Solid Organ Transplantation, Second Edition

How to Cite

Salama, A. D. (2007) Tolerance: A Review of Its Mechanisms in the Transplant Setting, in Pediatric Solid Organ Transplantation, Second Edition (eds R. N. Fine, S. A. Webber, K. M. Olthoff, D. A. Kelly and W. E. Harmon), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444312720.ch7

Editor Information

  1. 2

    Stony Brook University School of Medicine, Stony Brook, New York 11794-8111, USA

  2. 3

    University of Pittsburgh School of Medicine, Division of Cardiology, Children's Hospital, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA

  3. 4

    Liver Transplant Program, University of Pennsylvania and the Children's Hospital of Philadelphia, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104, USA

  4. 5

    The Liver Unit, Birmingham Children's Hospital NHS Trust, Steelhouse Lane, Birmingham, B4 6NH, UK

  5. 6

    Division of Nephrology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Hunn-319, Boston, MA 02115, USA

Author Information

  1. Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, UK

Publication History

  1. Published Online: 5 MAY 2009
  2. Published Print: 24 JAN 2007

ISBN Information

Print ISBN: 9781405124072

Online ISBN: 9781444312720

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Keywords:

  • antigen–immune cell encounter;
  • immunologic development;
  • donor-specific hyporesponsiveness;
  • anergic cells;
  • antigen-reactive T cells;
  • clinical organ transplantation;
  • well-functioning transplant;
  • chimeric immune systems;
  • donor-specific regulatory cell

Summary

This chapter contains sections titled:

  • Self and Transplantation Tolerance

  • Immunologic Changes Following Transplantation

  • Clinical Tolerance

  • Pediatric Issues

  • Conclusions

  • References