Chapter 10. Second Trimester Biochemical Screening for Neural Tube Defects and Aneuploidy

  1. John T. Queenan MD Professor Chairman Emeritus1,
  2. John C. Hobbins MD Professor of Obstetrics2 and
  3. Catherine Y. Spong MD Chief3
  1. John C. Hobbins MD Professor of Obstetrics

Published Online: 30 APR 2009

DOI: 10.1002/9781444312904.ch10

Protocols for High-Risk Pregnancies, Fourth Edition

Protocols for High-Risk Pregnancies, Fourth Edition

How to Cite

Hobbins, J. C. (2009) Second Trimester Biochemical Screening for Neural Tube Defects and Aneuploidy, in Protocols for High-Risk Pregnancies, Fourth Edition (eds J. T. Queenan, J. C. Hobbins and C. Y. Spong), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444312904.ch10

Editor Information

  1. 1

    Department of Obstetrics and Gynecology, Georgetown University School of Medicine, 3257 N Street NW, Washington, DC 20007, USA

  2. 2

    University of Colorado Health Sciences Center, Department of Obstetrics and Gynecology, 4200 East 9th Avenue, B-198, Denver, CO 80262, USA

  3. 3

    National Institute of Child Health and Human Development, Center for Developmental Biology and Perinatal Medicine, Pregnancy and Perinatology Branch, National Institutes of Health, 6100 Executive Bivd, Bethesda, MD 20892-7510, USA

Author Information

  1. University of Colorado Health Sciences Center, Department of Obstetrics and Gynecology, 4200 East 9th Avenue, B-198, Denver, CO 80262, USA

Publication History

  1. Published Online: 30 APR 2009
  2. Published Print: 9 SEP 2005

ISBN Information

Print ISBN: 9781405125796

Online ISBN: 9781444312904

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Keywords:

  • biochemical screening (BCS);
  • neural tube defects (NTDs);
  • maternal serum alpha-fetoprotein (MSAFP);
  • human chorionic gonadotropin (hCG);
  • age-related risk (ARR);
  • second trimester biochemical screening for neural tube defects and aneuploidy

Summary

This chapter contains sections titled:

  • Introduction

  • Screening for Neural Tube Defects

  • The Spine

  • Other Areas to Explore

  • Screening for down Syndrome

  • Contemporary Interpretation and Diagnostic Management of Biochemical Screening

  • Risk of Amniocentesis

  • Genetic Sonogram

  • Screening for Trisomy 18

  • Biochemical Screening and Adverse Pregnancy Outcome

  • Suggested Reading