Chapter 70. Rh and Other Blood Group Alloimmunizations

  1. John T. Queenan MD Professor Chairman Emeritus2,
  2. John C. Hobbins MD Professor of Obstetrics3 and
  3. Catherine Y. Spong MD Chief4
  1. Kenneth J. Moise Jr MD

Published Online: 30 APR 2009

DOI: 10.1002/9781444312904.ch70

Protocols for High-Risk Pregnancies, Fourth Edition

Protocols for High-Risk Pregnancies, Fourth Edition

How to Cite

Moise, K. J. (2005) Rh and Other Blood Group Alloimmunizations, in Protocols for High-Risk Pregnancies, Fourth Edition (eds J. T. Queenan, J. C. Hobbins and C. Y. Spong), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444312904.ch70

Editor Information

  1. 2

    Department of Obstetrics and Gynecology, Georgetown University School of Medicine, 3257 N Street NW, Washington, DC 20007, USA

  2. 3

    University of Colorado Health Sciences Center, Department of Obstetrics and Gynecology, 4200 East 9th Avenue, B-198, Denver, CO 80262, USA

  3. 4

    National Institute of Child Health and Human Development, Center for Developmental Biology and Perinatal Medicine, Pregnancy and Perinatology Branch, National Institutes of Health, 6100 Executive Bivd, Bethesda, MD 20892-7510, USA

Author Information

  1. University of North Carolina School of Medicine, Department of Obstetrics and Gynecology, 214 MacNider Building, CB#7516, Chapel Hill, NC 27599-7516, USA

Publication History

  1. Published Online: 30 APR 2009
  2. Published Print: 9 SEP 2005

ISBN Information

Print ISBN: 9781405125796

Online ISBN: 9781444312904

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Keywords:

  • Rh and other blood group alloimmunizations;
  • hydrops fetalis - significant manifestation of fetal anemia;
  • determination of paternal antigen status;
  • determining paternal zygosity (homozygous or heterozygous);
  • monitoring development of anemia in fetus - peak middle cerebral artery (MCA) Doppler velocity;
  • performing serial amniocenteses for DOD450 using Queenan curve;
  • prevention of RhD alloimmunization - use of specific immunoglobulin (RhIG)

Summary

This chapter contains sections titled:

  • Introduction

  • Pathophysiology

  • Management of the First Alloimmunized Pregnancy

  • Management of a Subsequent Alloimmunized Pregnancy

  • Treatment

  • Outcome and Follow-Up

  • Prevention

  • Conclusions

  • References