47. Drug Induced Liver Disease: Mechanisms and Diagnosis

  1. John WD McDonald Professor of Medicine3,
  2. Andrew K Burroughs Professor of Hepatology Consultant Physician/Hepatologist4,
  3. Brian G Feagan Professor of Medicine3 and
  4. M Brian Fennerty Professor of Medicine5
  1. Raúl J Andrade1 and
  2. M Isabel Lucena2

Published Online: 22 JUL 2010

DOI: 10.1002/9781444314403.ch47

Evidence-Based Gastroenterology and Hepatology, Third Edition

Evidence-Based Gastroenterology and Hepatology, Third Edition

How to Cite

Andrade, R. J. and Lucena, M. I. (2010) Drug Induced Liver Disease: Mechanisms and Diagnosis, in Evidence-Based Gastroenterology and Hepatology, Third Edition (eds J. W. McDonald, A. K. Burroughs, B. G. Feagan and M. B. Fennerty), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444314403.ch47

Editor Information

  1. 3

    Robarts Clinical Trials, Robarts Research Unit, University of Western Ontario, London, Ontario, Canada

  2. 4

    The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, and University College London, London, UK

  3. 5

    Oregon Health and Science University, Division of Gastroenterology and Hepatology, Portland, Oregon, USA

Author Information

  1. 1

    Liver Unit, Gastroenterology Service, “Virgen de la Victoria” University Hospital and School of Medicine, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Málaga, Spain

  2. 2

    Clinical Pharmacology Service, “Virgen de la Victoria” University Hospital and School of Medicine, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Málaga, Spain

Publication History

  1. Published Online: 22 JUL 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9781405181938

Online ISBN: 9781444314403

SEARCH

Keywords:

  • Diagnostic approach and tools for causality assessment;
  • Drug induced liver disease: Mechanisms and diagnosis;
  • drug-induced liver disease (DILI);
  • Chronic alcohol consumption;
  • CIOMS (Council for International Organizations of Medical Sciences);
  • RUCAM (Roussel Uclaf Causality Assessment Method);
  • hepatotoxicity or elevated transaminases on HAART;
  • The Manganese Superoxide Dismutase (MnSOD);
  • alaninoaminotransferases (ALT);
  • Naranjo Adverse Drug Reactions Probability Scale (NADRPS)

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanisms

  • Risk factors

  • Diagnostic approach and tools for causality assessment

  • References