6. Ulcer Disease and Helicobacter pylori Infection: Etiology and Treatment

  1. John WD McDonald Professor of Medicine3,
  2. Andrew K Burroughs Professor of Hepatology Consultant Physician/Hepatologist4,
  3. Brian G Feagan Professor of Medicine3 and
  4. M Brian Fennerty Professor of Medicine5
  1. Naoki Chiba1,2

Published Online: 22 JUL 2010

DOI: 10.1002/9781444314403.ch6

Evidence-Based Gastroenterology and Hepatology, Third Edition

Evidence-Based Gastroenterology and Hepatology, Third Edition

How to Cite

Chiba, N. (2010) Ulcer Disease and Helicobacter pylori Infection: Etiology and Treatment, in Evidence-Based Gastroenterology and Hepatology, Third Edition (eds J. W. McDonald, A. K. Burroughs, B. G. Feagan and M. B. Fennerty), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444314403.ch6

Editor Information

  1. 3

    Robarts Clinical Trials, Robarts Research Unit, University of Western Ontario, London, Ontario, Canada

  2. 4

    The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, and University College London, London, UK

  3. 5

    Oregon Health and Science University, Division of Gastroenterology and Hepatology, Portland, Oregon, USA

Author Information

  1. 1

    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Canada

  2. 2

    Guelph General Hospital, Guelph, Canada

Publication History

  1. Published Online: 22 JUL 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9781405181938

Online ISBN: 9781444314403

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Keywords:

  • What is the evidence for the role of H. pylori in peptic ulcer disease?;
  • Association of H. pylori with ulcer disease (strength, consistency and specificity);
  • Effects of interventions: outcomes following H. pylori eradication;
  • Coherence of the data with earlier epidemiological information;
  • Treatment of duodenal ulcer;
  • Treatment of gastric ulcer;
  • non-steroidal anti-inflammatory drugs (NSAIDs);
  • Duodenal ulcers not related to H. pylori and NSAIDs;
  • mucosa-associated lymphoid tissue (MALT);
  • duodenal ulcer promoting gene (dupA)

Summary

This chapter contains sections titled:

  • Introduction

  • What is the evidence for the role of H. pylori in peptic ulcer disease?

  • Association of H. pylori with ulcer disease (strength, consistency and specificity)

  • Temporal relationship

  • Biological gradient

  • Effects of interventions: outcomes following H. pylori eradication

  • Coherence of the data with earlier epidemiological information

  • Treatment of duodenal ulcer

  • Treatment of gastric ulcer

  • H. pylori eradication therapy

  • Summary

  • References