Chapter 1. Shock

  1. Mark J. D. Griffiths MRCP, PhD, EDICM, BDICM Consultant,
  2. Jeremy J. Cordingley MRCP, FRCA, EDICM Consultant and
  3. Susanna Price MRCP, PhD, EDICM, FESC Consultant
  1. Marius Terblanche Consultant1 and
  2. Nicole Assmann MD, FRCA Consultant Anaesthetist2

Published Online: 9 JUL 2010

DOI: 10.1002/9781444314502.ch1

Cardiovascular Critical Care

Cardiovascular Critical Care

How to Cite

Terblanche, M. and Assmann, N. (2010) Shock, in Cardiovascular Critical Care (eds M. J. D. Griffiths, J. J. Cordingley and S. Price), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444314502.ch1

Editor Information

  1. Royal Brompton & Harefield NHS Foundation Trust London, UK

Author Information

  1. 1

    Critical Care Medicine, Guy's & St Thomas' Hospital, London, UK

  2. 2

    Royal Free Hospital, London, UK

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 30 JUL 2010

ISBN Information

Print ISBN: 9781405148573

Online ISBN: 9781444314502



  • hypoxia inducible factor (HIF);
  • the sympathetic nervous system (SNS);
  • vasoconstriction increases mean arterial pressure (MAP);
  • Pattern recognition receptors (PRRs);
  • Other high output shock states;
  • Effects of activation of the pro-inflammatory system;
  • protein C system and tissue factor pathway inhibitor (TFPI);
  • Neuro-endocrine system


This chapter contains sections titled:

  • Introduction

  • Low output states

  • High output states

  • The pathway to organ failure

  • Conclusion

  • References