Chapter 4. Calcium Hydroxylapatite Microspheres in Facial Augmentation

  1. Derek Jones Director Founder Clinical Associate Professor
  1. Alastair Carruthers MA, BM, BCH, FRCPC, FRCP (Lon) Clinical Professor1 and
  2. Jean Carruthers MD, FRCS (C), FRC(Ophth) Clinical Professor2

Published Online: 10 MAR 2010

DOI: 10.1002/9781444315004.ch4

Injectable Fillers: Principles and Practice

Injectable Fillers: Principles and Practice

How to Cite

Carruthers, A. and Carruthers, J. (2010) Calcium Hydroxylapatite Microspheres in Facial Augmentation, in Injectable Fillers: Principles and Practice (ed D. Jones), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444315004.ch4

Editor Information

  1. David Geffin School of Medicine, University of California, Los Angeles, USA

Author Information

  1. 1

    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada

  2. 2

    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada

Publication History

  1. Published Online: 10 MAR 2010
  2. Published Print: 31 MAR 2010

ISBN Information

Print ISBN: 9781405192897

Online ISBN: 9781444315004

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Keywords:

  • Calcium hydroxylapatite;
  • Radiesse;
  • subdermal volume filler;
  • facial lipoatrophy;
  • intrinsic facial aging;
  • carboxymethyl cellulose gel carrier;
  • fibroblastic response;
  • nasolabial folds;
  • nasal contouring

Summary

Radiesse consists of calcium hydroxylapatite microspheres in an aqueous carboxymethyl cellulose gel carrier. It is injected through a 27 gauge needle into the subdermal space or even above the periosteum. After injection, the gel carrier is absorbed and the microspheres act as a scaffold for new tissue formation inducing a fibroblastic response which improves volume deficits in excess of one year. The main uses for Radiesse have been volume loss correction due to intrinsic aging, particularly in the cheek/chin area and also in HIV associated facial lipoatrophy. Radiesse has also proven useful for nasal contouring. Radiesse appears to be very safe with few significant adverse events other than those expected from injecting a material of this kind into the subdermal space such as pain, swelling, bruising