Chapter 7. Liquid Injectable Silicone

  1. Derek Jones Director Founder Clinical Associate Professor
  1. Chad L. Prather MD Director Clinical Assistant Professor1,2

Published Online: 10 MAR 2010

DOI: 10.1002/9781444315004.ch7

Injectable Fillers: Principles and Practice

Injectable Fillers: Principles and Practice

How to Cite

Prather, C. L. (2010) Liquid Injectable Silicone, in Injectable Fillers: Principles and Practice (ed D. Jones), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444315004.ch7

Editor Information

  1. David Geffin School of Medicine, University of California, Los Angeles, USA

Author Information

  1. 1

    Department of Dermatology, Louisiana State University, New Orleans, USA

  2. 2

    Dermasurgery Center, Baton Rouge, Louisiana, USA

Publication History

  1. Published Online: 10 MAR 2010
  2. Published Print: 31 MAR 2010

ISBN Information

Print ISBN: 9781405192897

Online ISBN: 9781444315004



  • Silicone;
  • liquid injectable silicone;
  • dimethylpolysiloxanes;
  • silicone oils


Liquid injectable silicone (LIS) is a unique and permanent soft tissue augmenting agent that may be effectively employed for various cutaneous and subcutaneous atrophies, and is particularly suited for the correction of facial lipoatrophy. LIS may be safely utilized, with minimal complications, when modern, FDA-approved products are injected in small quantities over several treatment sessions exclusively with the microdroplet serial puncture technique. Historical, anecdotal reports regarding the safety and complication rates of silicone are currently being supplanted by data from ongoing controlled trials, and a clearer image of LIS as a safe, efficacious, and practical augmenting agent is emerging. However, when choosing LIS over other fillers, both patient and physician should have ample insight into the ramifications of its permanence, which include a sustained and cost-effective aesthetic result, but also the potential for complications that might require a more aggressive course of treatment than is necessary with temporary fillers