Chapter 32. Adrenocorticotropic Hormone and Corticosteroids

  1. Simon Shorvon MA, MB, BChir, MD, FRCP Professor in Clinical Neurology Consultant Neurologist2,3,
  2. Emilio Perucca MD, PhD, FRCP(Edin) Professor of Medical Pharmacology Director4,5 and
  3. Jerome Engel Jr MD, PhD Director Professor of Neurology6,7
  1. Federico Vigevano Director of Neuroscience Department and
  2. Maria Roberta Cilio Attending Neurologist

Published Online: 22 JUL 2009

DOI: 10.1002/9781444316667.ch32

The Treatment of Epilepsy, Third Edition

The Treatment of Epilepsy, Third Edition

How to Cite

Vigevano, F. and Cilio, M. R. (2009) Adrenocorticotropic Hormone and Corticosteroids, in The Treatment of Epilepsy, Third Edition (eds S. Shorvon, E. Perucca and J. Engel), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444316667.ch32

Editor Information

  1. 2

    UCL Institute of Neurology, University College London, London, United Kingdom

  2. 3

    National Hospital for Neurology and Neurosurgery, London, United Kingdom

  3. 4

    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy

  4. 5

    Clinical Trial Center, Institute of Neurology IRCCS C Mondino Foundation, Pavia, Italy

  5. 6

    Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA

  6. 7

    UCLA Seizure Disorder Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Author Information

  1. Bambino Gesù Children's Hospital, Rome, Italy

Publication History

  1. Published Online: 22 JUL 2009
  2. Published Print: 24 JUL 2009

ISBN Information

Print ISBN: 9781405183833

Online ISBN: 9781444316667



  • adrenocorticotropic hormone (ACTH) and corticosteroids;
  • adrenocorticotropic hormone and corticosteroids;
  • pharmacokinetics;
  • corticosteroid metabolism;
  • epileptic syndromes;
  • ACTH and corticosteroids and adverse effects


This chapter contains sections titled:

  • Introduction

  • Chemistry

  • Mechanisms of action

  • Pharmacokinetics

  • Drug interactions

  • Serum level monitoring

  • Efficacy

  • Adverse effects

  • Current place in therapy

  • References