Chapter 4. Impulse Initiation and Propagation in Cardiac Muscle

  1. José Jalife MD Professor of Internal Medicine Professor of Molecular & Integrative Physiology1,2,
  2. Mario Delmar MD, PhD Professor of Internal Medicine3,4,
  3. Justus Anumonwo PhD Assistant Professor of Internal Medicine5,
  4. Omer Berenfeld PhD Assistant Professor of Internal Medicine and Biomedical Engineering5 and
  5. Jérôme Kalifa MD, PhD Assistant Professor of Internal Medicine5

Published Online: 15 JUL 2009

DOI: 10.1002/9781444316940.ch4

Basic Cardiac Electrophysiology for the Clinician, Second Edition

Basic Cardiac Electrophysiology for the Clinician, Second Edition

How to Cite

Jalife, J., Delmar, M., Anumonwo, J., Berenfeld, O. and Kalifa, J. (2009) Impulse Initiation and Propagation in Cardiac Muscle, in Basic Cardiac Electrophysiology for the Clinician, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444316940.ch4

Author Information

  1. 1

    The Cyrus and Jane Farrehi Professor of Cardiovascular Research, University of Michigan, Ann Arbor, Michigan, USA

  2. 2

    Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

  3. 3

    Frank Norman Wilson Professor of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA

  4. 4

    Molecular & Integrative Physiology Co-Director, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

  5. 5

    Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA

Publication History

  1. Published Online: 15 JUL 2009
  2. Published Print: 29 MAY 2009

ISBN Information

Print ISBN: 9781405183338

Online ISBN: 9781444316940

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Keywords:

  • impulse initiation and cardiac muscle propagation;
  • cell-to-cell communication for electrical impulse generation;
  • resistive coupling and mutual entrainment;
  • immunofluorescence localization techniques;
  • phase–response curve (PRC);
  • mutual entrainment and heartbeat generation;
  • cardiac impulse propagation;
  • cable equations characterizing current and voltage changes;
  • current load and liminal length concept

Summary

This chapter contains sections titled:

  • Electrotonic Propagation

  • Pacemaker Synchronization in the Sinus Node

  • Resistive Coupling and Mutual Entrainment

  • The Phase-Response Curve Predicts Entrainment

  • Interaction of Two Pacemakers (Mutual Entrainment)

  • Mutual Entrainment and the Generation of the Heartbeat

  • Propagation of the Cardiac Impulse

  • Cable Equations

  • Propagation of the Action Potential: “Sink” and “Source”

  • Current Load and the Concept of Liminal Length

  • Factors Regulating Action Potential Propagation in Cardiac Tissues

  • Concept of “Safety Factor” for Propagation

  • Propagation in Two Dimensions and the Concept of Curvature

  • Anisotropic Propagation

  • Propagation in Three-Dimensional Cardiac Muscle

  • Propagation at Junctional Sites

  • Heterocellular Interactions and Their Role on Propagation

  • Summary