Chapter 5. Rate Dependency of Discontinuous Propagation

  1. José Jalife MD Professor of Internal Medicine Professor of Molecular & Integrative Physiology1,2,
  2. Mario Delmar MD, PhD Professor of Internal Medicine3,4,
  3. Justus Anumonwo PhD Assistant Professor of Internal Medicine5,
  4. Omer Berenfeld PhD Assistant Professor of Internal Medicine and Biomedical Engineering5 and
  5. Jérôme Kalifa MD, PhD Assistant Professor of Internal Medicine5

Published Online: 15 JUL 2009

DOI: 10.1002/9781444316940.ch5

Basic Cardiac Electrophysiology for the Clinician, Second Edition

Basic Cardiac Electrophysiology for the Clinician, Second Edition

How to Cite

Jalife, J., Delmar, M., Anumonwo, J., Berenfeld, O. and Kalifa, J. (2009) Rate Dependency of Discontinuous Propagation, in Basic Cardiac Electrophysiology for the Clinician, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444316940.ch5

Author Information

  1. 1

    The Cyrus and Jane Farrehi Professor of Cardiovascular Research, University of Michigan, Ann Arbor, Michigan, USA

  2. 2

    Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

  3. 3

    Frank Norman Wilson Professor of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA

  4. 4

    Molecular & Integrative Physiology Co-Director, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

  5. 5

    Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA

Publication History

  1. Published Online: 15 JUL 2009
  2. Published Print: 29 MAY 2009

ISBN Information

Print ISBN: 9781405183338

Online ISBN: 9781444316940

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Keywords:

  • discontinuous propagation rate dependency;
  • dynamics and ionic mechanisms of complex patterns of propagation;
  • Wenckebach periodicity - cellular mechanisms;
  • continuous versus discontinuous propagation;
  • basic cycle length (BCL) of stimulation;
  • postrepolarization refractoriness;
  • sink and source properties and discontinuous propagation;
  • ionic mechanisms of Wenckebach-like patterns in ventricular myocytes;
  • nonlinear recovery and complex excitation dynamics

Summary

This chapter contains sections titled:

  • Continuous versus Discontinuous Propagation

  • Postrepolarization Refractoriness

  • Cellular Mechanisms of Discontinuous Propagation

  • Unidirectional Block

  • Cellular Mechanisms of Wenckebach Periodicity

  • Recovery Curve

  • Recovery Curve Predicts Nonlinear Dynamics of Rate-Dependent Propagation

  • Ionic Mechanism of Wenckebach in Ventricular and Atrioventricular Nodal Myocytes

  • Nonlinear Recovery and Complex Excitation Dynamics

  • Role of Gross Anatomic Structure in Discontinuous Propagation

  • The Phenomenon of Fibrillatory Conduction

  • Summary