Chapter 8. Rotors and the Mechanisms of Atrial Fibrillation

  1. José Jalife MD Professor of Internal Medicine Professor of Molecular & Integrative Physiology1,2,
  2. Mario Delmar MD, PhD Professor of Internal Medicine3,4,
  3. Justus Anumonwo PhD Assistant Professor of Internal Medicine5,
  4. Omer Berenfeld PhD Assistant Professor of Internal Medicine and Biomedical Engineering5 and
  5. Jérôme Kalifa MD, PhD Assistant Professor of Internal Medicine5

Published Online: 15 JUL 2009

DOI: 10.1002/9781444316940.ch8

Basic Cardiac Electrophysiology for the Clinician, Second Edition

Basic Cardiac Electrophysiology for the Clinician, Second Edition

How to Cite

Jalife, J., Delmar, M., Anumonwo, J., Berenfeld, O. and Kalifa, J. (2009) Rotors and the Mechanisms of Atrial Fibrillation, in Basic Cardiac Electrophysiology for the Clinician, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444316940.ch8

Author Information

  1. 1

    The Cyrus and Jane Farrehi Professor of Cardiovascular Research, University of Michigan, Ann Arbor, Michigan, USA

  2. 2

    Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

  3. 3

    Frank Norman Wilson Professor of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA

  4. 4

    Molecular & Integrative Physiology Co-Director, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

  5. 5

    Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA

Publication History

  1. Published Online: 15 JUL 2009
  2. Published Print: 29 MAY 2009

ISBN Information

Print ISBN: 9781405183338

Online ISBN: 9781444316940

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Keywords:

  • rotors and atrial fibrillation mechanisms;
  • atrial (AF) and ventricular (VF) fibrillation in humans;
  • sheep model of atrial fibrillation;
  • reentrant activity and wavebreak formation;
  • generated waves across Bachmann's bundle (BB);
  • left atrium-to-right atrium frequency gradients;
  • intra-atrial pressure (IAP) and stretch-related AF dynamics;
  • bipolar electrograms and corresponding power spectra

Summary

This chapter contains sections titled:

  • Mechanism of Atrial Fibrillation: Multiple Wavelets versus Mother Rotor

  • The Sheep Model of Atrial Fibrillation

  • Wavebreak and Initiation of Reentry in the Atria

  • A Single Reentrant Source may Drive Atrial Fibrillation

  • Left Atrium-to-Right Atrium Frequency Gradients

  • Dispersion of Activation Rate during Atrial Fibrillation

  • Stretch and Activation in the Left Atrium during Atrial Fibrillation

  • Vagal Effects on Rotors during Atrial Fibrillation

  • Ionic Mechanisms of Parasympathetic Modulation of Atrial Fibrillation

  • Remodeling of the Atrial Substrate in Chronic Atrial Fibrillation

  • Atrial Fibrillation in Humans: The Spatial Distribution of Dominant Frequencies

  • Activation Frequency and Rotors as Atrial Fibrillation Drivers in Humans

  • Summary