Chapter 102. Isolated Inflammatory Demyelinating Syndromes (IIDS)

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Ernest W. Willoughby MB ChB, FRACP Neurologist Clinical Associate Professor (Hon.)

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch102

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Willoughby, E. W. (2009) Isolated Inflammatory Demyelinating Syndromes (IIDS), in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch102

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • isolated inflammatory demyelinating syndromes (IIDS);
  • “clinically isolated syndrome” (CIS);
  • acute disseminated encephalomyelitis (ADEM);
  • cerebrospinal fluid (CSF), showing mild lymphocytic pleocytosis;
  • intravenous immunoglobulin (IVIG);
  • Uhthoff's phenomenon;
  • cerebral hemisphere inflammatory lesions


This chapter contains sections titled:

  • Introduction

  • Features common to all of the syndromes

  • Optic neuritis

  • (Transverse) myelitis

  • Brainstem inflammatory lesions

  • Cerebral hemisphere inflammatory lesions

  • Further reading