Chapter 115. Lambert–Eaton Syndrome

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Johan A. Aarli MD Professor

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch115

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Aarli, J. A. (2009) Lambert–Eaton Syndrome, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch115

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Haukeland University Hospital, Bergen, Norway

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008

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Keywords:

  • Lambert–Eaton syndrome;
  • LEMS, presynaptic neuromuscular disorder - circulating antibodies against presynaptic voltage-gated calcium channels (VGCC);
  • “myasthenic syndrome” because of its clinical similarities with myasthenia gravis;
  • LEMS, first described in patients - with malignant tumors, especially SCLC;
  • LEMS main symptoms - muscle weakness and fatigue, especially of legs;
  • LEMS diagnosis - extensive search for underlying cancer being important;
  • patients with LEMS, responding to prednisolone, and immunotherapy

Summary

This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Investigations

  • Treatment/management

  • Further reading