Chapter 119. Familial Periodic Paralyses

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Chokri Mhiri MD Professor of Neurology Head

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch119

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Mhiri, C. (2009) Familial Periodic Paralyses, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch119

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Habib Bourguiba University Hospital, Sfax, Tunisia

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • familial periodic paralyses (FPP) - autosomal dominant disorders due to abnormal sarcolemmal excitability secondary to ion channel dysfunction;
  • FPP, classified as hypokalemic (hypoKPP) or hyperkalemic (hyperKPP);
  • hypokalemic periodic paralysis (MIM170400);
  • onset age, earlier in hyperKPP than in hypoKPP;
  • FPP diagnosis, with transient episodes of paralysis and family history;
  • muscle biopsy, showing fiber size variation, nuclear centralization, target fibers, subsarcolemmal vacuoles;
  • hypokalemia or hyperkalemia correction - well tolerated, risks reverse rebound


This chapter contains sections titled:

  • Introduction

  • Clinical features

  • Diagnosis

  • Genetics

  • Treatment/management

  • Further reading