Chapter 131. Low Grade and Anaplastic Oligodendroglioma

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief3,4,
  2. Daniel D. Truong MD, FAAN Head5,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head6 and
  4. Roongroj Bhidayasiri MD, FRCP Director7,8
  1. Ayman I. Omar MD, PhD Fellow1,2 and
  2. Warren P. Mason MD, FRCPC Associate Professor1,2

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch131

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Omar, A. I. and Mason, W. P. (2009) Low Grade and Anaplastic Oligodendroglioma, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch131

Editor Information

  1. 3

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 4

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 5

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 6

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 7

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 8

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. 1

    Princess Margaret Hospital, Toronto, Canada

  2. 2

    University of Toronto, Toronto, Canada

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • low grade and anaplastic oligodendroglioma;
  • low grade oligoastrocytomas (OA) and anaplastic oligoastrocytomas (AOA);
  • single most important predictor of outcome for patients - with oligodendroglial tumors is histological grade;
  • microscopically, low grade ODs - containing sheets of rounded cells with perinuclear halo classic, “fried-egg appearance”;
  • OD management;
  • RT, effective treatment modality for controlling gliomas;
  • AOD management - surgery and radiation therapy;
  • surgery and RT - treatment modalities for treatment of AOD;
  • chemo- and radiosensitivity of oligodendroglial tumors - optimal management remaining highly controversial


This chapter contains sections titled:

  • Introduction

  • Epidemiology and prognosis

  • Pathology and molecular biology

  • Clinical picture

  • Imaging

  • Treatment

  • Conclusions

  • Further reading