Chapter 136. Medulloblastoma

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Regina I. Jakacki MD Associate Professor of Pediatrics Director

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch136

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Jakacki, R. I. (2009) Medulloblastoma, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch136

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Children's Hospital of Pittsburgh, Pittsburgh, PA, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • medulloblastoma;
  • medulloblastomas (MB) or primitive neuroectodermal tumors (PNET) of cerebellum;
  • craniospinal irradiation (CSI) - optimizing likelihood of cure;
  • obtaining spinal MRI prior to surgical resection - being optimal;
  • Children's Cancer Group (CCG) study;
  • medulloblastomas, not curable with surgery alone - quite responsive to radiation and chemotherapy;
  • histologic differentiation along glial, neuronal, and/or ependymal lines;
  • standard dose chemotherapy, not sufficient to allow a reduction in craniospinal dose for patients


This chapter contains sections titled:

  • Overview

  • Presentation

  • Diagnosis and surgery

  • Staging evaluation

  • Prognostic factors (Table 136.1)

  • Treatment

  • Further reading