Chapter 137. Primary Central Nervous System Lymphoma (CNSL)

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief3,4,
  2. Daniel D. Truong MD, FAAN Head5,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head6 and
  4. Roongroj Bhidayasiri MD, FRCP Director7,8
  1. Deborah T. Blumenthal MD Adjunct Associate Professor1,2

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch137

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Blumenthal, D. T. (2010) Primary Central Nervous System Lymphoma (CNSL), in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch137

Editor Information

  1. 3

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 4

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 5

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 6

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 7

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 8

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. 1

    Tel-Aviv University, Tel-Aviv, Israel

  2. 2

    University of Utah, Salt Lake City, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008

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Keywords:

  • primary central nervous system lymphoma (CNSL);
  • CNSL, similar histologically to systemic large B-cell lymphomas;
  • CNSL incidence, increasing in the 1990s and 2000s;
  • primary CNSL, involving cerebrospinal fluid (CSF);
  • axial T1 gadolinium-enhanced MRI - densely enhancing solitary mass in area of right temporal trigone;
  • HIV/AIDS-related CNSL;
  • CNSL, recognized as one of AIDS-defining illnesses in HIV-positive patient;
  • treatment-related toxicity

Summary

This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Investigations

  • Prognosis and treatment

  • Salvage therapy

  • Treatment-related toxicity

  • HIV/AIDS-related CNSL

  • Treatment guidelines, clinical trials, and future direction

  • Further reading