Chapter 141. General Approach to the Diagnosis and Treatment of Paraneoplastic Neurologic Disorders

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Myrna R. Rosenfeld MD, PhD, FAAN Professor of Neurology Chief and
  2. Josep O. Dalmau MD, PhD Professor of Neurology Director

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch141

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Rosenfeld, M. R. and Dalmau, J. O. (2009) General Approach to the Diagnosis and Treatment of Paraneoplastic Neurologic Disorders, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch141

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • paraneoplastic neurologic disorders - diagnosis and treatment;
  • paraneoplastic neurologic disorders (PND) - immune-mediated disorders;
  • serum and cerebrospinal fluid (CSF) of antibodies - reacting with antigens;
  • syndromes of neuromuscular junction and muscle;
  • Combined CT and 18-fluorodeoxyglucose positron emission tomography (FDG-PET);
  • paraneoplastic cerebellar degeneration (PCD);
  • paraneoplastic encephalomyelitis (PEM) - patients with PEM, dysfunction of any part of CNS;
  • limbic encephalitis (LE) - patients with paraneoplastic LE presenting with anxiety, depression, confusion, delirium, hallucinations


This chapter contains sections titled:

  • Introduction

  • Diagnosis

  • Treatment

  • Specific syndromes

  • Further reading