Chapter 143. Narcolepsy

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief3,4,
  2. Daniel D. Truong MD, FAAN Head5,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head6 and
  4. Roongroj Bhidayasiri MD, FRCP Director7,8
  1. Marcel Hungs MD, PhD Assistant Professor Director1 and
  2. Emmanuel Mignot MD, PhD2

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch143

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Hungs, M. and Mignot, E. (2009) Narcolepsy, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch143

Editor Information

  1. 3

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 4

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 5

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 6

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 7

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 8

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. 1

    University of California, Irvine, USA

  2. 2

    Stanford University Center for Narcolepsy, Palo Alto, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • narcolepsy, common sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, sleep paralysis;
  • narcolepsy, along with obstructive sleep apnea (OSA) and idiopathic hypersomnia;
  • prevalence of narcolepsy with cataplexy in North America and Europe;
  • occurrence of narcolepsy - involving genetic predisposition and environmental triggers;
  • sleep paralysis - patients with narcolepsy, experiencing sleep paralysis and inability to move for seconds;
  • excessive daytime sleepiness - often the first symptom of narcolepsy;
  • management and treatment of narcolepsy - life-modifying interventions and medications targeting disabling symptoms


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Diagnosis

  • Treatment/management

  • Further reading