Chapter 156. Floppy Infant Syndrome

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Jong-Hee Chae MD, PhD Associate Professor

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch156

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Chae, J.-H. (2009) Floppy Infant Syndrome, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch156

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • floppy infant syndrome;
  • floppy infant syndrome, disease in which infants present with generalized hypotonia at birth or early infancy;
  • floppy infants, characteristic “frog-leg posture,” excessive joint mobility and profound weakness;
  • metachromatic leukodystrophy and Pelizaeus–Merzbacher disease - showing pathologies;
  • cost-effective use of laboratory investigations;
  • floppy infant syndrome - possible causes;
  • congenital myopathies - classic myopathies, as nemaline myopathy, central core disease, centronuclear or myotubular myopathy;
  • Floppy infant syndrome - having highly variable etiologies


This chapter contains sections titled:

  • Introduction

  • Clinical evaluation

  • Laboratory investigations

  • Diagnostic approach

  • Conclusion

  • Further reading